Self‐Reported Health and Outcomes in Patients With Stable Coronary Heart Disease
Identifieur interne : 000385 ( Main/Exploration ); précédent : 000384; suivant : 000386Self‐Reported Health and Outcomes in Patients With Stable Coronary Heart Disease
Auteurs : Ralph A. H. Stewart ; Emil Hagström ; Claes Held ; Tom Kai Ming Wang ; Paul W. Armstrong ; Philip E. Aylward ; Christopher P. Cannon ; Wolfgang Koenig ; José Luis L Pez-Send N ; Emile R. Mohler ; Nermin Hadziosmanovic ; Susan Krug-Gourley ; Marco Antonio Ramos Corrales ; Saulat Siddique ; Philippe Gabriel Steg ; Harvey D. White ; Lars WallentinSource :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease [ 2047-9980 ] ; 2017.
Abstract
The major determinants and prognostic importance of self‐reported health in patients with stable coronary heart disease are uncertain.
The STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial randomized 15 828 patients with stable coronary heart disease to treatment with darapladib or placebo. At baseline, 98% of participants completed a questionnaire that included the question, “Overall, how do you feel your general health is now?” Possible responses were
Self‐reported health is strongly associated with geographical region, mood, and physical activity. In a global coronary heart disease population, self‐reported health was independently associated with major cardiovascular events and mortality beyond what is measurable by established risk indicators.
Url:
DOI: 10.1161/JAHA.117.006096
PubMed: 28862971
PubMed Central: 5586450
Affiliations:
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H." last="Stewart">Ralph A. H. Stewart</name><affiliation><nlm:aff id="jah32465-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Hagstrom, Emil" sort="Hagstrom, Emil" uniqKey="Hagstrom E" first="Emil" last="Hagström">Emil Hagström</name><affiliation><nlm:aff id="jah32465-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Held, Claes" sort="Held, Claes" uniqKey="Held C" first="Claes" last="Held">Claes Held</name><affiliation><nlm:aff id="jah32465-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Wang, Tom Kai Ming" sort="Wang, Tom Kai Ming" uniqKey="Wang T" first="Tom Kai Ming" last="Wang">Tom Kai Ming Wang</name><affiliation><nlm:aff id="jah32465-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Armstrong, Paul W" sort="Armstrong, Paul W" uniqKey="Armstrong P" first="Paul W." last="Armstrong">Paul W. 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Cannon</name><affiliation><nlm:aff id="jah32465-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="jah32465-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="jah32465-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="jah32465-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="L Pez End N, Jose Luis" sort="L Pez End N, Jose Luis" uniqKey="L Pez End N J" first="José Luis" last="L Pez-Send N">José Luis L Pez-Send N</name><affiliation><nlm:aff id="jah32465-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Mohler, Emile R" sort="Mohler, Emile R" uniqKey="Mohler E" first="Emile R." last="Mohler">Emile R. Mohler</name><affiliation><nlm:aff id="jah32465-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Hadziosmanovic, Nermin" sort="Hadziosmanovic, Nermin" uniqKey="Hadziosmanovic N" first="Nermin" last="Hadziosmanovic">Nermin Hadziosmanovic</name><affiliation><nlm:aff id="jah32465-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Krug Ourley, Susan" sort="Krug Ourley, Susan" uniqKey="Krug Ourley S" first="Susan" last="Krug-Gourley">Susan Krug-Gourley</name><affiliation><nlm:aff id="jah32465-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Ramos Corrales, Marco Antonio" sort="Ramos Corrales, Marco Antonio" uniqKey="Ramos Corrales M" first="Marco Antonio" last="Ramos Corrales">Marco Antonio Ramos Corrales</name><affiliation><nlm:aff id="jah32465-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Siddique, Saulat" sort="Siddique, Saulat" uniqKey="Siddique S" first="Saulat" last="Siddique">Saulat Siddique</name><affiliation><nlm:aff id="jah32465-aff-0013"></nlm:aff></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation><nlm:aff id="jah32465-aff-0014"></nlm:aff></affiliation><affiliation><nlm:aff id="jah32465-aff-0015"></nlm:aff></affiliation><affiliation><nlm:aff id="jah32465-aff-0016"></nlm:aff></affiliation><affiliation><nlm:aff id="jah32465-aff-0017"></nlm:aff></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation><nlm:aff id="jah32465-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name><affiliation><nlm:aff id="jah32465-aff-0002"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease</title><idno type="eISSN">2047-9980</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="jah32465-sec-0001"><title>Background</title><p>The major determinants and prognostic importance of self‐reported health in patients with stable coronary heart disease are uncertain.</p></sec><sec id="jah32465-sec-0002"><title>Methods and Results</title><p>The STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial randomized 15 828 patients with stable coronary heart disease to treatment with darapladib or placebo. At baseline, 98% of participants completed a questionnaire that included the question, “Overall, how do you feel your general health is now?” Possible responses were <italic>excellent, very good, good, average</italic>, and <italic>poor</italic>. Adjudicated major adverse cardiac events, which included cardiovascular death, myocardial infarction, and stroke, were evaluated by Cox regression during 3.7 years of follow‐up for participants who reported excellent or very good health (n=2304), good health (n=6863), and average or poor health (n=6361), before and after adjusting for 38 covariates. Self‐reported health was most strongly associated with geographic region, depressive symptoms, and low physical activity (<italic>P</italic><0.0001 for all). Poor/average compared with very good/excellent self‐reported health was independently associated with major adverse cardiac events (hazard ratio [<styled-content style="fixed-case">HR</styled-content>]: 2.30 [95% confidence interval (<styled-content style="fixed-case">CI</styled-content>), 1.92–2.76]; adjusted <styled-content style="fixed-case">HR</styled-content>: 1.83 [95% <styled-content style="fixed-case">CI</styled-content>, 1.51–2.22]), cardiovascular mortality (<styled-content style="fixed-case">HR</styled-content>: 4.36 [95% <styled-content style="fixed-case">CI</styled-content>, 3.09–6.16]; adjusted <styled-content style="fixed-case">HR</styled-content>: 2.15 [95% <styled-content style="fixed-case">CI</styled-content>, 1.45–3.19]), and myocardial infarction (<styled-content style="fixed-case">HR</styled-content>: 1.87 [95% <styled-content style="fixed-case">CI</styled-content>, 1.46–2.39]; adjusted <styled-content style="fixed-case">HR</styled-content>: 1.68 [95% <styled-content style="fixed-case">CI</styled-content>, 1.25–2.27]; <italic>P</italic><0.0002 for all).</p></sec><sec id="jah32465-sec-0003"><title>Conclusions</title><p>Self‐reported health is strongly associated with geographical region, mood, and physical activity. In a global coronary heart disease population, self‐reported health was independently associated with major cardiovascular events and mortality beyond what is measurable by established risk indicators.</p></sec><sec id="jah32465-sec-0004"><title>Clinical Trial Registration</title><p><styled-content style="fixed-case">URL</styled-content>: <ext-link ext-link-type="uri" xlink:href="http://www.ClinicalTrials.gov">http://www.ClinicalTrials.gov</ext-link>. Unique identifier: <styled-content style="fixed-case">NCT</styled-content>00799903.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Armstrong, Paul W" sort="Armstrong, Paul W" uniqKey="Armstrong P" first="Paul W." last="Armstrong">Paul W. Armstrong</name><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E." last="Aylward">Philip E. Aylward</name><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P." last="Cannon">Christopher P. Cannon</name><name sortKey="Hadziosmanovic, Nermin" sort="Hadziosmanovic, Nermin" uniqKey="Hadziosmanovic N" first="Nermin" last="Hadziosmanovic">Nermin Hadziosmanovic</name><name sortKey="Hagstrom, Emil" sort="Hagstrom, Emil" uniqKey="Hagstrom E" first="Emil" last="Hagström">Emil Hagström</name><name sortKey="Held, Claes" sort="Held, Claes" uniqKey="Held C" first="Claes" last="Held">Claes Held</name><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><name sortKey="Krug Ourley, Susan" sort="Krug Ourley, Susan" uniqKey="Krug Ourley S" first="Susan" last="Krug-Gourley">Susan Krug-Gourley</name><name sortKey="L Pez End N, Jose Luis" sort="L Pez End N, Jose Luis" uniqKey="L Pez End N J" first="José Luis" last="L Pez-Send N">José Luis L Pez-Send N</name><name sortKey="Mohler, Emile R" sort="Mohler, Emile R" uniqKey="Mohler E" first="Emile R." last="Mohler">Emile R. Mohler</name><name sortKey="Ramos Corrales, Marco Antonio" sort="Ramos Corrales, Marco Antonio" uniqKey="Ramos Corrales M" first="Marco Antonio" last="Ramos Corrales">Marco Antonio Ramos Corrales</name><name sortKey="Siddique, Saulat" sort="Siddique, Saulat" uniqKey="Siddique S" first="Saulat" last="Siddique">Saulat Siddique</name><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><name sortKey="Stewart, Ralph A H" sort="Stewart, Ralph A H" uniqKey="Stewart R" first="Ralph A. H." last="Stewart">Ralph A. H. Stewart</name><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name><name sortKey="Wang, Tom Kai Ming" sort="Wang, Tom Kai Ming" uniqKey="Wang T" first="Tom Kai Ming" last="Wang">Tom Kai Ming Wang</name><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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